Noni juice
Common name
noni, morinda, Indian mulberry, hog apple, canarywood
ID
HD0049
Scientific name of the plant
Morinda citrifolia L.
Anatomical part for use
fruit
Human use
Miscellaneous
Summary
Morinda citrifolia is a fruit-bearing tree in the coffee family, Rubiaceae. Its native range extends across Southeast Asia and Australasia, and was spread across the Pacific by Polynesian sailors. The species is now cultivated throughout the tropics and widely naturalized. Among some 100 names for the fruit across different regions are the more common English names of great morinda, Indian mulberry, noni, beach mulberry, and cheese fruit.The fresh fruit's strong, vomit-like odor has made it a famine food in most regions, but it remains a staple food among some cultures, and has been used in traditional medicine. In the consumer market, it has been introduced as a supplement in various formats, such as capsules, skin products, and juices. (Source: Wiki)
Evidence Level
Level 4 (Individual reports repeated observed over 5 years among different countries)
Hepatotoxicity reports in literature
- Herbal hepatotoxicity: acute hepatitis caused by a Noni preparation (Morinda citrifolia) : (Source)
- Hepatotoxicity of NONI juice: report of two cases : (Source)
- Hepatitis induced by Noni juice from Morinda citrifolia: a rare cause of hepatotoxicity or the tip of the iceberg? : (Source)
- [Hepatotoxicity caused by a Noni (Morinda citrifolia) preparation] : (Source)
- Herbal does not at all mean innocuous: the sixth case of hepatotoxicity associated with morinda citrifolia (noni) : (Source)
- Acute hepatotoxicity after ingestion of Morinda citrifolia (Noni Berry) juice in a 14-year-old boy : (Source)
- Drug-Induced Liver Injury Associated with Noni (Morinda citrifolia) Juice and Phenobarbital : (Source)
Hepatotoxicity Description
Several case reports have suggested that noni may account for some cases of idiosyncratic acute liver injury, although the association was weak in many cases. The latency to onset ranged from 2 to 8 weeks and the clinical features resembled acute hepatitis with a hepatocellular pattern of serum enzyme elevations. Immunoallergic features (rash, fever, eosinophilia) were not present, but some patients had high levels of autoantibodies. Nevertheless, the liver injury resolved rapidly once noni was discontinued and other features of autoimmunity were not present. (Source: LiverTox)
Traditional medicine
Green fruit, leaves, and root or rhizomes might have been used in Polynesian cultures as a general tonic, in addition to its traditional place in Polynesian culture as a famine food. Although Morinda is considered to have biological properties in traditional medicine, there is no confirmed evidence of clinical efficacy for any intended use. In 2018, a Hawaiian manufacturer of noni food and skincare products was issued an FDA warning letter for marketing unapproved drugs and making false health claims in violation of the US Food, Drug and Cosmetic Act. (Source: Wiki)
Common name
noni, morinda, Indian mulberry, hog apple, canarywood
ID
HD0049
Scientific name of the plant
Morinda citrifolia L.
Anatomical part for use
fruit
Human use
Miscellaneous
Summary
Morinda citrifolia is a fruit-bearing tree in the coffee family, Rubiaceae. Its native range extends across Southeast Asia and Australasia, and was spread across the Pacific by Polynesian sailors. The species is now cultivated throughout the tropics and widely naturalized. Among some 100 names for the fruit across different regions are the more common English names of great morinda, Indian mulberry, noni, beach mulberry, and cheese fruit.The fresh fruit's strong, vomit-like odor has made it a famine food in most regions, but it remains a staple food among some cultures, and has been used in traditional medicine. In the consumer market, it has been introduced as a supplement in various formats, such as capsules, skin products, and juices. (Source: Wiki)
Evidence Level
Level 4 (Individual reports repeated observed over 5 years among different countries)
Hepatotoxicity reports in literature
- Herbal hepatotoxicity: acute hepatitis caused by a Noni preparation (Morinda citrifolia) : (Source)
- Hepatotoxicity of NONI juice: report of two cases : (Source)
- Hepatitis induced by Noni juice from Morinda citrifolia: a rare cause of hepatotoxicity or the tip of the iceberg? : (Source)
- [Hepatotoxicity caused by a Noni (Morinda citrifolia) preparation] : (Source)
- Herbal does not at all mean innocuous: the sixth case of hepatotoxicity associated with morinda citrifolia (noni) : (Source)
- Acute hepatotoxicity after ingestion of Morinda citrifolia (Noni Berry) juice in a 14-year-old boy : (Source)
- Drug-Induced Liver Injury Associated with Noni (Morinda citrifolia) Juice and Phenobarbital : (Source)
Hepatotoxicity Description
Several case reports have suggested that noni may account for some cases of idiosyncratic acute liver injury, although the association was weak in many cases. The latency to onset ranged from 2 to 8 weeks and the clinical features resembled acute hepatitis with a hepatocellular pattern of serum enzyme elevations. Immunoallergic features (rash, fever, eosinophilia) were not present, but some patients had high levels of autoantibodies. Nevertheless, the liver injury resolved rapidly once noni was discontinued and other features of autoimmunity were not present. (Source: LiverTox)
Traditional medicine
Green fruit, leaves, and root or rhizomes might have been used in Polynesian cultures as a general tonic, in addition to its traditional place in Polynesian culture as a famine food. Although Morinda is considered to have biological properties in traditional medicine, there is no confirmed evidence of clinical efficacy for any intended use. In 2018, a Hawaiian manufacturer of noni food and skincare products was issued an FDA warning letter for marketing unapproved drugs and making false health claims in violation of the US Food, Drug and Cosmetic Act. (Source: Wiki)